If you've been bodybuilding or working out for a while now, then you probably have heard about Selective Androgen Receptor Modulators (SARMs) like RAD 140 and LGD 4033. They've sparked a lot of attention recently, and there's been many people curious on which one is better.
In this post, we will take a critical look at these two leading SARMs in order to clarify their effects on your training, how safe they are, any known side effects as well as any other useful information that can help you to make an informed decision while choosing which of these products to use. Let’s get right into it!
RAD 140 is also commonly referred to as Testolone. This SARM is hugely popular among gym rats because of the noticeable results that it has notched up in terms of building lean muscle mass and boosting strength.
When compared to other selective androgen receptor modulators, RAD 140 is miles ahead of the rest in terms of facilitating gaining lean muscle mass.
RAD 140 Studies
It is understandable if you are a little skeptical about the claims of the miraculous effects of RAD 140 and you are interested in hearing what the existing science has to say about this compound. Here is the science nerd stuff you need to know about Testolone.
Originally, Radius Pharmaceuticals developed RAD 140 in 2010 with the sole aim of dealing with the severe muscle loss suffered by people with breast cancer. It was also intended to address the loss of bone density in those patients.
However, people in the fitness and bodybuilding world soon got wind of this compound and started using it, with remarkable results.
A 2010 study done using monkeys and mice as the test subjects concluded that RAD 140 displayed all the characteristic hallmarks of a SARM since it mainly activated the androgen receptors in the muscles and bones without any significant impact on similar receptors in the testicles or prostate gland.
This preclinical toxicology and efficacy profile of Testolone was deemed to be satisfactory enough to warrant further research in human subjects. At the moment, no human studies of RAD 140 have been published but you can bet you will be the first to know once they are completed.
RAD 140 Dosage
Since Testolone hasn’t been studied in humans and it hasn’t been approved as a drug, there is currently no ironclad information about the recommended dosage that you can take in order to enjoy its reported benefits.
That said, the members of the bodybuilding community who have used RAD 140 recommend a daily dosage of between 10mg and 20 mg of this SARM for men and 5-10 mg of RAD per day for women.
Each person is different, so it is best to start small, such as at 5mg a day for men, and observe how your body responds to Testolone. If you don’t notice any unpleasant side effects, gradually increase the dosage until you reach the maximum recommended dose per day.
It is also important for you to note that RAD 140 should be taken for a cycle that ranges between 6 and 10 weeks at max. After, it is recommended to stop taking the RAD-140 for an off-duration of 6-8 weeks before deciding to start another RAD 140 cycle. Depending on the person, you may need PCT.
RAD 140 Side Effects
As already mentioned, there isn’t a lot of scientific data available about RAD 140, so most of the information about the possible side effects of taking this compound may be anecdotal. However, the available research indicates that side effects of Testolone are somewhat mild and quickly subside. These include a short temper, increased aggression and headaches.
It seems that these side effects are triggered when someone takes more than the recommended daily dose of 10-20mg, so the best way to avoid those side effects is by sticking to the recommended amounts or lower.
LGD 4033, also known as Ligandrol, is also a selective androgen receptor modulator (SARM). It was originally developed by Ligand Pharmaceuticals, hence the name Ligandrol.
However, Viking Therapeutics acquired Ligandrol Pharmaceuticals and Viking is now in charge of the current R&D (research and development) of this SARM.
Like RAD 140, LGD 4033 wasn’t developed for the bodybuilding or fitness community. Rather, it was primarily developed to treat people suffering from osteoporosis and those afflicted by conditions that caused their muscles to waste away rapidly.
However, the bodybuilding and fitness crowd soon got their hands on this selective androgen receptor modulator and the rest, as they say, is history.
LGD 4033 works largely by building body strength, stamina and endurance. Because of this added power under the hood, bodybuilders are able to work out a lot more and this in turn triggers the growth of lean muscle. For this reason, it is common to hear people say that they have noticed that they develop more lean muscle when they take LGD 4033.
Ligandrol works by activating the androgen receptors in the bones and muscles, so these parts of the body will exhibit the greatest benefit of protein synthesis and growth. Other androgen receptors in the sex organs and elsewhere exhibit limited response to this compound, so they aren’t affected by the activity of LGD 4033.
LGD 4033 Studies
In truth, there is a dire need for human trials to be conducted on LGD 4033 because, as of writing this post, only one trial has so far been done. This study involved 76 healthy males all aged between 21 and 50 years.
The researchers gave the study participants either a placebo or varying daily doses of LGD 4033 (0.1mg, 0.3mg or 1.0mg) for a total of 21 days. The intention was to establish whether Ligandrol was safe to consume and whether it was well tolerated by the body.
The study was also designed to shed some light on whether the compound was beneficial or had an effect on one’s sex hormones, stair-climbing ability, muscle strength and lean body mass.
It was found that LGD 4033 was indeed tolerated by the body, helped increase lean muscle mass, and didn’t have any effect on the PSA (prostate-specific antigen) readings of the participants.
As you may have noticed, the study population was rather small, so there is need for larger clinical studies to be done in order to ascertain the exact role played by Ligandrol. Nevertheless, this available research paints a good picture of what LGD 4033 can do.
LGD 4033 Dosage
The recommended daily dosage for LGD 4033 ranges from 5mg to 10mg. however, it is advisable for you to start on the lower end of this range, and then slowly increase the dosage as you take note of how your body is responding.
People who have used this compound say it should be taken for a cycle lasting between 6 and 12 weeks, after which you need to refrain from taking LGD 4033 for 4-8 weeks before starting another cycle.
This dosage is likely to give you results of lean muscle gain of approximately 1-1.5 pounds each week, but results may vary depending on several individual factors, such as your diet and workout regimen.
LGD 4033 Side Effects
You may be pleased to learn that based on the current research and anecdotal reports about Ligandrol, the compound doesn’t appear to have any side effects. However, some people have reported mild testosterone suppression, and that is why you may need a PCT (post-cycle therapy) product to reset your testosterone production.
Stacking RAD 140 vs. LGD 4033
If you have followed the discussion above closely regarding the benefits and main uses of each of the selective androgen receptor modulators RAD 140 and LGD 4033, you may be wondering whether it would be prudent to stack them (use them both) so that you can get the best of both worlds.
Indeed many bodybuilders or fitness enthusiasts have done exactly that. However, you should proceed with caution if you also want to stack these two compounds.
This is because using them together may increase the likelihood and severity of any side effects that you may be prone to, so being under the watchful eye of an experienced medical practitioner may be necessary so that you are monitored and given professional advice during every step of your journey.
Which One is Better: LGD-4033 or RAD-140?
Since stacking these products may carry a heightened risk of suffering side effects, you may be wondering which of the two you should choose if you are to take one and not the other.
The short answer is that it depends. Since both products have documented benefits, your choice will depend on your personal goals. For example, if you are most interested in taking your strength, endurance and stamina to the next level, then LGD 4033 is the best for you.
However, if your primary goal is to bulge up your muscles, then RAD 140 will offer exactly what you want. So, take your pick! Remember, the use of SARMs hasn’t been approved by the World Anti-Doping Agency (WADA), so proceed with caution if you engage in any competitive sports.